Porvair evaporators are designed to remove the traditional laboratory ‘bottleneck’ of solvent evaporation from microplates prior to analysis or reconstitution in storage buffer. These evaporators give significant throughput advantages to laboratories looking to optimize microplate sample preparation productivity. Faster than centrifugal evaporation, significant increases in sample throughput are achieved through advanced evaporator head technology and an innovative manifold design, which directly injects heated nitrogen into each individual well of the microplate simultaneously.
The evaporators have been designed to be simple to install, operate and maintain. Installation requires only connection to a gas supply or cylinder and mains electricity. Safety of operation is ensured as the CE marked compact units fit into all fume cupboards. Not suitable for high boiling solvents such as DMSO and water. Both MiniVap and UltraVap may be operated with a supply of clean, dry compressed air in place of nitrogen, if the chemistry allows. An in-line gas filter must be used in this case.
The MiniVap is purpose designed for low usage research and development departments where low numbers of individual plates or vials need drying. The MiniVap is simple to operate and maintain. Installation requires only connection to a gas supply and standard mains socket. With manual control of the needle depth, gas temperature and flow rate, it allows fine control and quicker drying times than other standard methods. Porvair Sciences new versions of its MiniVap and UltraVap blowdown evaporators use warm air or nitrogen to speed up the evaporation of common HPLC solvents such as dichloromethane, methanol and acetonitrile from sample vials, significantly improving throughput and removing this common laboratory bottleneck. Combining a new 48-well needle head with a dedicated HPLC vial holder that accepts 48 standard 1.5ml vials* transforms any MiniVap or UltraVap system into a high throughput HPLC sample evaporator.
Applications that will benefit from the new HPLC sample evaporators include pre-concentration prior to injection (to increase sensitivity) as well as evaporation to dryness of post-column fractions for recovery of compounds.
- Quicker dry down times than standard methods such as vacuum oven
- Tests have shown that the MiniVap can evaporate 500μl of methanol in less than 6 minutes
- Designed for any SBS/ANSI 96 well plate
- 24 vial head now available
- Simple to install and operate
- Easy adjustments of temperature, gas flow rates and needle depth into the wells
- Compact footprint – fits all standard fume cupboards
The Ultravap Levante is the latest from Porvair Sciences’ popular series of nitrogen blow-down sample concentrators and evaporators. Using technology from our very successful Ultravap Mistral series of robot-ready, integration compatible evaporators we have re-designed the classic single plate evaporator to meet the needs of the modern laboratory.
Now you get full-colour touch screen graphic displays, an integrated auto-ranging power supply and built-in fume venting. Combined with real-time run displays showing actual gas temperature, gas flow rate and stage height the Ultravap Levante puts you more in control of the evaporation process. Offering multi-step ramped programming with full alphanumeric program naming, the Levante is our state-of-the-art standalone evaporator.
The precision engineered mechanism uses a standard ANSI/SLAS plate “nest” to accept most microplate formats and tube racks. It can accommodate tubes up to 80mm in height in a variety of configurations to allow the use of 2 Dram vials, 1.5ml HPLC vials, bar-coded tubes in racks and many other common formats. Evaporator heads are made to match these formats in 24-, 48-, 96- and 384-well configurations. Our unique 96-well spiral needle head, which creates a vortex in certain plates to speed up evaporation, can also be used on the Ultravap Levante.
Designed to give you long life in the laboratory, Ultravap Series evaporators are robustly built with solid aluminium billet sides, steel cover plates powder-coated for solvent resistance and wide large rubber feet for bench top mounting. The Levante has a built-in fume duct and an optional fan unit is available to speed solvent vapour removal away from the plate, thus increasing the evaporation rate further. New auto-ranging 110/220V power supplies eliminate the need for a transformer and provide sufficient power to drive the heaters and motor without drawing an excessive load, thereby extending the life of your instrument.
Precision Swiss-made stepper motors are used in all Ultravaps to precisely control the upward movement of the stage in 0.1cm increments, ensuring that with careful programming, the evaporator head remains just above the surface of the liquid to be removed for optimum efficiency. An on-board digital flow controller allows accurate programming of real gas flow rates for the first time, ensuring reproducible results every time.
Ultravap Levante can be operated from both a gas cylinder and an in-house supply of nitrogen or clean dry air. The blow-down technique is very useful for removing chromatography solvents such as dichloromethane, acetonitrile, methanol and hexane. However, it is not suitable for higher boiling solvents such as DMF, DMSO and large quantities of water.
The Ultravap Levante comes with an RS232 connection and a remote command set. Whilst not sporting the smart plate “shuttle” of the premium Ultravap Mistral, it is still possible to connect to and operate from a robot liquid handling station using the Ultravap Levante. This should appeal to the budget-conscious laboratory who may wish to automate the dry-down bottleneck in the future.
The Ultravap Levante is supplied with an evaporator head of your choice, which may be interchanged quickly and easily with a head of a different pattern as your workflow demands.
The Ultravap Mistral from Porvair Sciences is designed to remove the traditional laboratory ‘bottleneck’ of solvent evaporation from microplates. It is our most sophisticated automation-friendly model yet, giving significant throughput advantages to laboratories looking to optimise microplate sample preparation. Faster than centrifugal evaporation for single plates, significant increases in sample throughput are achieved through advanced evaporator head technology and an innovative manifold design, which directly injects heated nitrogen into each individual well of the microplate simultaneously. Installation requires only connection to a gas supply and mains electricity. Safety of operation is ensured as this CE-marked compact unit fits into all fume cupboards and boasts full integral fume management within the unit. The UltraVap Mistral may be operated with a supply of clean, dry compressed air in place of nitrogen, if the chemistry allows. An in-line gas filter must be used in this case.
The new Ultravap Mistral is the latest fully robotcompatible nitrogen blow-down evaporator, suitable for integration adjacent to several leading laboratory liquid handling robots. Designed with the demands of linear robots very much in mind, the Ultravap Mistral offers a plate shuttle which can serve and retrieve plates from the deck of Perkin Elmer, Tecan, Hamilton and Beckman liquid handlers. The colour touch-screen controlled dry down station accepts 24-, 48-, 96- or 384-well plates and comes complete with clear safety side screens and integral fume management leading to a 4 inch duct adaptor. Flexible programming
The Ultravap Mistral has been designed to allow robots with standard gripper arms to place and remove microplates directly onto the shuttle. In comparison with previous models, the Ultravap Mistral has a 10% smaller footprint, allowing better access and saving valuable bench space. The evaporation table is able to rise under the control of a stepper motor as the drying process proceeds. This can be programmed at a suitable rate for each solvent type being evaporated. In addition, gas temperature, pressure and flow rate can all be programmed individually and stored in up to thirty multistep programmes on the Ultravap Mistral controller. Each programme allows the table to rise in up to five distinct ramped phases, so that a fast initial drying period can be followed by a gentler final drying phase.
The new Ultravap Mistral lends itself to full integration with most robotic liquid handlers, where it is usually located on the right-hand side of the deck. Control commands are sent directly from the robot controller to the Ultravap. These standard commands are listed in the manual, but most robot manufacturers have drivers available to control the Ultravap, making integration a seamless process.
With a choice of 96 straight or 96 spiral needles, plus 24, 48 and 384 straight needles, the sphere of application for With a choice of 96 straight or 96 spiral needles, plus 24, 48 and 384 straight needles, the sphere of application for Ultravap Mistral is huge. Most common chromatography solvents can be evaporated with ease, such as dichloromethane, methanol, acetonitrile and hexane. The nitrogen blow-down method is not, however, suitable for high-boiling point solvents such as DMF, DMSO and water. It is also unable to be used with acids or acid chlorides, as special corrosion-resistant systems are needed for this work. The choice of straight or spiral needles allows the user to choose between faster dry down (spiral) and better final drying in V-well plates (straight). The spirals cause a vortex to form in the solvent, increasing the surface area and thus speeding up the rate of evaporation.
Evaporator System Requirements
Gas flow rate: 28L/min minimum, 80L/min maximum at 6 bar pressure. Can be used with nitrogen or dry compressed air if the chemistry allows. Not suitable for use with strong acids or acid chlorides.
- Fully liquid handling robot compatible dry down station
- Plate shuttle sends/retrieve plates from robot deck
- Adjustable shuttle position and height Intuitive graphical colour touch screen display
- Up to 30 stored evaporation programmes
- Up to 5 programmable steps per method On board gas management
- Master & multiple slave configuration supported
- Remote control from PC option
- Reversible screen for integration at side of robot
- Built in fume management and duct connector
- Faster evaporation times
- Choice of 384, 96, 48 & 24 well heads Small footprint to fit in your hood
|MiniVap||UltraVap Levante||UltraVap Mistral|