SiliaMetS E-PAK: Rapid and Reliable Adsorption Processing

Adsorbent Cartridges versus Loose Media

Until recently the use of activated carbon and silica-based Metal Scavengers was largely try to be avoided in API manufacturing due to handling and safety issues. Filtration and chromatography products converted to incorporate activated carbon or silica gel have provided handling and safety improvements for pilot scale use but done little to address the practical requirements of large-scale processing. Graver Technologies, producer of Ecosorb® Products, and SiliCycle, producer of SiliaMetS Metal […]

2019-01-24T14:55:13+01:00Categories: Product Highlight|Tags: , |

SiliCycle Launches 4 New Scavengers

SiliCycle delivers easier, cleaner, faster, more efficient purification processes using scavengers: those are silica gels functionalized with various molecules featuring scavenging properties toward different metals and / or organics. They have now added 4 novel scavengers to their portfolio, which was already one of the broadest on the market:

  • SiliaBond Guanidine for organic compounds scavenging, a silica-supported diisopropylguanidine ligand. It is a very powerful scavenger for the chelating of organic acids in general, especially boronic […]
2019-01-25T13:01:55+01:00Categories: Product Highlight|Tags: |

Removal of Boronic Acids

Boronic acids and their derivatives are one of the most widespread ubiquitous intermediates and reagents in organic and medicinal synthesis.

On-the-market drugs have even been adding boron atoms to enhance compatibility, selectivity and potency to their target molecules. Up to very recently, boronic acids had always been reported as lacking apparent toxicity, mutagenic activity or in vivo instability issues.

New studies have raised objections about this safe toxicological profile, both based on experimental and clinical data.

This is […]

2019-02-15T15:44:22+01:00Categories: How To / Guide, Technical Note|Tags: |

Metal Scavengers: Typical Conditions

In need of scavenging metals? The SiliaBond® Metal Scavenger range will suit your needs. We recommend performing some screening (on small scale) using the SiliaBond Metal Scavenger Kit (e.g product # K30730B) to quickly determine which scavenger presents the highest efficiency and make experiment optimization from there.

Upon completion of the screening procedure, the scavenging is not completed and you are not satisfied with the scavenging efficiency or you wish to reduce the number of equivalents and […]

2019-02-15T15:43:51+01:00Categories: How To / Guide, Technical Note|Tags: , |

Heavy Metals and Regulations

In recent years, the presence of metal impurities has become a major issue in the drug-making industry, and thus, the need for its effective removal. The time pressure associated for drug candidates to quickly reach the market has greatly increased the number of metal-catalysed reactions progressing from lead optimization to early scale-up.

For almost two years now, the International Conference on Harmonisation (ICH) has been working on its Q3D guidelines for metal elemental impurities in new […]

2019-02-15T15:43:25+01:00Categories: How To / Guide, Technical Note|Tags: , |